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Deletion Boy Speyer Kif3a results in the total absence of cilia and has been an important tool to study cilia function. Kif3a and Kif17 have been described to have varying roles in primary cilia.
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APAR status Closed giide program error. In zebrafish Kif17 has tissue Steve Bottrop dating site roles, being required for photoreceptor formation but not for ciliogenesis in the pronephros . MDCK cells embedded in type I collagen develop spherical structures, where the apical membrane forms a central lumen and the basal membranes are oriented towards the surrounding matrix.
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These data uncover that Kif3a regulates the microtubular cytoskeleton in the cell periphery and gyide that extra-ciliary Kif3a has an unexpected function in morphogenesis. Kif3a is a subunit of hetero-trimeric Kinesin-2, a microtubule MT plus-end directed motor protein .
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